But if you are wanting an autograph from Stan Lee, plan on waiting in line a LONG TIME. I ended up not getting an autograph from him last year because I was only there for one day and the whole day would have been spent waiting in his line (and I bought an extra MOC Standor figure specifically for him to sign).
I did get the photo op, which was a lot easier. It was done separately from the autographs. Basically twice during the day for about a half hour each time, they had him in a separate area for the photos. For both the autographs and photo ops, everyone paid ahead in a separate line, so when it came time for the photos, they basically rush everyone through. It's basically stand next to Stan, pose, snap the picture, and you are on your way. Kind of inpersonal, but it was efficient, and allowed me to check out the rest of the con.
I don't know if they'll be handling it any differently this year, but that's how it went down last year.